\u00b7\u4ece1940\u5e74\u4ee3scurfy\u5c0f\u9f20\u7684\u5076\u7136\u53d1\u73b0\uff0c\u52301960\u5e74\u4ee3\u7684\u80f8\u817a\u5207\u9664\u5b9e\u9a8c\uff0c\u518d\u52301990\u5e74\u4ee3\u7684\u5206\u5b50\u751f\u7269\u5b66\u7a81\u7834\uff0c\u5982\u4eca\uff0c\u4e16\u754c\u5404\u5730\u7684\u5b9e\u9a8c\u5ba4\u548c\u533b\u9662\u6b63\u5728\u5c06\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u4e34\u5e8a\u5e94\u7528\u3002\u65e0\u8bba\u662f\u9971\u53d7\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6298\u78e8\u7684\u60a3\u8005,\u8fd8\u662f\u7b49\u5f85\u5668\u5b98\u79fb\u690d\u7684\u75c5\u4eba,\u6291\u6216\u662f\u4e0e\u764c\u75c7\u6297\u4e89\u7684\u52c7\u58eb,\u90fd\u53ef\u80fd\u4ece\u8fd9\u4e09\u4f4d\u79d1\u5b66\u5bb6\u7684\u5de5\u4f5c\u4e2d\u83b7\u76ca\u3002<\/p>\n
\u5317\u4eac\u65f6\u95f410\u67086\u65e517\u65f630\u5206\uff0c2025\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5728\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u63ed\u6653\u3002\u5956\u9879\u6388\u4e88\u4e86\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\u3001\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u4ee3\u5c14\uff08Fred Ramsdell\uff09\u548c\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u5916\u5468\u514d\u75ab\u8010\u53d7\u65b9\u9762\u7684\u53d1\u73b0\u3002<\/p>\n
\u8fd9\u4e09\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u73b0\u5e76\u5b9a\u4e49\u4e86\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u5173\u952e\u201c\u7ef4\u548c\u90e8\u961f\u201d\u2014\u2014\u8c03\u8282\u6027T\u7ec6\u80de\uff08Regulatory T cells, Tregs\uff09\uff0c\u4e3a\u514d\u75ab\u5b66\u7814\u7a76\u5f00\u8f9f\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u9886\u57df\u3002\u8fd9\u4e00\u91cc\u7a0b\u7891\u5f0f\u7684\u53d1\u73b0\u4e0d\u4ec5\u6df1\u523b\u6539\u53d8\u4e86\u6211\u4eec\u5bf9\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u4fdd\u6301\u5e73\u8861\u7684\u7406\u89e3\uff0c\u66f4\u4e3a\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u63d0\u5347\u764c\u75c7\u7597\u6548\u4ee5\u53ca\u9632\u6b62\u5668\u5b98\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u5e26\u6765\u4e86\u65b0\u7684\u7b56\u7565\u3002<\/p>\n
2025\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u83b7\u5956\u8005\uff08\u5de6\u8d77\uff09\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\u3001\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u4ee3\u5c14\uff08Fred Ramsdell\uff09\u548c\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\u3002<\/p>\n
\u201c\u4ed6\u4eec\u7684\u53d1\u73b0\u81f3\u5173\u91cd\u8981\uff0c\u4e0d\u4ec5\u6df1\u5316\u4e86\u6211\u4eec\u5bf9\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u7684\u7406\u89e3\uff0c\u8fd8\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u591a\u6570\u4e2a\u4f53\u4e0d\u4f1a\u60a3\u4e0a\u4e25\u91cd\u7684\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u201d\u8bfa\u8d1d\u5c14\u59d4\u5458\u4f1a\u4e3b\u5e2dOlleK\u01cempe \u8868\u793a\u3002<\/p>\n
\u514d\u75ab\u7cfb\u7edf\u7684\u201c\u7ef4\u548c\u90e8\u961f\u201d<\/p>\n
\u6211\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u662f\u4e00\u90e8\u6f14\u5316\u53f2\u4e0a\u7684\u6770\u4f5c\u3002\u5b83\u50cf\u4e00\u652f\u7cbe\u9510\u519b\u961f\uff0c\u6bcf\u5929\u4fdd\u62a4\u6211\u4eec\u514d\u53d7\u65e0\u6570\u75c5\u6bd2\u3001\u7ec6\u83cc\u7684\u4fb5\u88ad\u3002\u8fd9\u652f\u519b\u961f\u6700\u795e\u5947\u7684\u80fd\u529b\u4e4b\u4e00\u662f\u80fd\u591f\u7cbe\u51c6\u8bc6\u522b\u201c\u53cb\u519b\u201d\u548c\u201c\u654c\u4eba\u201d\uff0c\u4ece\u800c\u5728\u653b\u51fb\u5165\u4fb5\u8005\u7684\u540c\u65f6\u4fdd\u62a4\u81ea\u8eab\u7ec4\u7ec7\u3002<\/p>\n
\u8fd9\u5957\u7cbe\u5bc6\u7684\u654c\u6211\u8bc6\u522b\u7cfb\u7edf\u662f\u5982\u4f55\u8fd0\u4f5c\u7684\uff1f\u4e3a\u4ec0\u4e48\u5b83\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\u4e0d\u4f1a\u201c\u53db\u53d8\u201d\u653b\u51fb\u6211\u4eec\u81ea\u5df1\uff1f<\/p>\n
\u5f88\u957f\u4e00\u6bb5\u65f6\u95f4\u91cc\uff0c\u79d1\u5b66\u5bb6\u4eec\u8ba4\u4e3a\u7b54\u6848\u5728\u4e8e\u201c\u4e2d\u592e\u8010\u53d7\u201d\u673a\u5236\u3002T\u7ec6\u80de\u662f\u514d\u75ab\u7cfb\u7edf\u7684\u6838\u5fc3\u201c\u5175\u79cd\u201d\uff0c\u5b83\u4eec\u5728\u80f8\u817a\uff08thymus\uff09\u8fd9\u4e2a\u201c\u519b\u4e8b\u5b66\u9662\u201d\u4e2d\u6210\u719f\u3002\u5728\u8fd9\u91cc\uff0c\u90a3\u4e9b\u80fd\u591f\u8bc6\u522b\u5e76\u653b\u51fb\u81ea\u8eab\u7ec4\u7ec7\u7684\u201c\u5371\u9669\u201dT\u7ec6\u80de\u4f1a\u88ab\u4e25\u683c\u7b5b\u9009\u5e76\u6e05\u9664\uff0c\u5c31\u50cf\u662f\u5728\u65b0\u5175\u5165\u4f0d\u524d\u8fdb\u884c\u4e25\u683c\u5ba1\u6838\uff0c\u786e\u4fdd\u4ed6\u4eec\u4e0d\u4f1a\u6210\u4e3a\u5185\u90e8\u7684\u5a01\u80c1\u3002<\/p>\n
\u4f46\u662f\uff0c\u5982\u679c\u6709\u201c\u6f0f\u7f51\u4e4b\u9c7c\u201d\u4f1a\u4ece\u80f8\u817a\u201c\u6bd5\u4e1a\u201d\u5e76\u8fdb\u5165\u8840\u6db2\u5faa\u73af\u5927\u8086\u641e\u7834\u574f\uff0c\u514d\u75ab\u7cfb\u7edf\u662f\u5426\u6709\u5e94\u5bf9\u7684\u673a\u5236\uff1f\u65e9\u5728\u4e0a\u4e16\u7eaa70\u5e74\u4ee3\uff0c\u5c31\u6709\u5b66\u8005\u63d0\u51fa\u4e86\u201c\u6291\u5236\u6027T\u7ec6\u80de\u201d\u7684\u5047\u8bf4\uff0c\u8ba4\u4e3a\u5b58\u5728\u4e00\u79cd\u7ec6\u80de\u4e13\u95e8\u8d1f\u8d23\u7ba1\u675f\u8fd9\u4e9b\u201c\u53db\u53d8\u201d\u7684T\u7ec6\u80de\u3002\u7531\u4e8e\u65e9\u671f\u7814\u7a76\u8bc1\u636e\u4e0d\u8db3\uff0c\u6574\u4e2a\u5047\u8bf4\u88ab\u5b66\u754c\u629b\u5f03\uff0c\u76f8\u5173\u7814\u7a76\u4e5f\u9677\u5165\u4e86\u4f4e\u8c37\u3002<\/p>\n
\u4e0a\u4e16\u7eaa80\u5e74\u4ee3\uff0c\u672c\u6b21\u83b7\u5956\u8005\u4e4b\u4e00\u7684\u5742\u53e3\u5fd7\u6587\u53d7\u5230\u4e00\u4e2a\u53cd\u5e38\u5b9e\u9a8c\u7684\u542f\u53d1\uff1a\u5982\u679c\u5728\u5c0f\u9f20\u51fa\u751f\u540e\u7b2c\u4e09\u5929\u5207\u9664\u5176\u80f8\u817a\uff0c\u5b83\u4eec\u7684\u514d\u75ab\u7cfb\u7edf\u975e\u4f46\u6ca1\u6709\u53d8\u5f31\uff0c\u53cd\u800c\u4f1a\u5931\u63a7\u201c\u66b4\u8d70\u201d\uff0c\u5bfc\u81f4\u5c0f\u9f20\u60a3\u4e0a\u591a\u79cd\u81ea\u8eab\u514d\u75ab\u75c5\u3002\u8fd9\u6697\u793a\u7740\u80f8\u817a\u4e0d\u4ec5\u662fT\u7ec6\u80de\u7684\u8bad\u7ec3\u573a\uff0c\u8fd8\u53ef\u80fd\u751f\u4ea7\u4e86\u67d0\u79cd\u80fd\u7ed9\u514d\u75ab\u7cfb\u7edf\u201c\u8e29\u5239\u8f66\u201d\u7684\u7ec6\u80de\u3002<\/p>\n
\u5742\u53e3\u5fd7\u6587\u575a\u4fe1\u514d\u75ab\u7cfb\u7edf\u4e2d\u5fc5\u7136\u5b58\u5728\u8fd9\u6837\u4e00\u652f\u201c\u7ef4\u548c\u90e8\u961f\u201d\uff0c\u5e76\u4e8e\u5176\u540e\u7684\u5341\u591a\u5e74\u4e2d\u8fdb\u884c\u4e86\u4e0d\u61c8\u5730\u7814\u7a76\u30021995\u5e74\uff0c\u4ed6\u5728\u300a\u514d\u75ab\u5b66\u6742\u5fd7\u300b\uff08The Journal of Immunology\uff09\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u91cc\u7a0b\u7891\u5f0f\u7684\u8bba\u6587\u3002\u4ed6\u53d1\u73b0\uff0c\u5728\u8f85\u52a9\u6027T\u7ec6\u80de\uff08\u901a\u5e38\u5e26\u6709CD4\u86cb\u767d\u6807\u5fd7\uff09\u4e2d\uff0c\u5b58\u5728\u4e00\u4e2a\u7279\u6b8a\u7684\u4e9a\u7fa4\uff0c\u5b83\u4eec\u8868\u9762\u4e0d\u4ec5\u6709CD4\uff0c\u8fd8\u9ad8\u6c34\u5e73\u8868\u8fbe\u4e00\u79cd\u540d\u4e3aCD25\u7684\u86cb\u767d\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u6b63\u662f\u8fd9\u7fa4T\u7ec6\u80de\u626e\u6f14\u7740\u6291\u5236\u514d\u75ab\u53cd\u5e94\u3001\u9632\u6b62\u81ea\u8eab\u653b\u51fb\u7684\u5173\u952e\u89d2\u8272\u3002<\/p>\n
\u5742\u53e3\u5fd7\u6587\u627e\u5230\u4e86\u8fd9\u652f\u201c\u7ef4\u548c\u90e8\u961f\u201d\uff0c\u5e76\u5c06\u5b83\u4eec\u547d\u540d\u4e3a\u201c\u8c03\u8282\u6027T\u7ec6\u80de\u201d\uff08Tregs\uff09\uff0c\u4f46\u5f53\u65f6\u8bb8\u591a\u4eba\u5bf9\u6b64\u4ecd\u6301\u6000\u7591\u6001\u5ea6\u3002\u66f4\u786e\u51ff\u7684\u8bc1\u636e\u6700\u7ec8\u6765\u81ea\u5927\u6d0b\u5f7c\u5cb8\u7684\u53e6\u4e24\u4f4d\u79d1\u5b66\u5bb6\u548c\u4e00\u4e2a\u9057\u4f20\u5b66\u7814\u7a76\u4e0a\u7684\u5076\u7136\u3002<\/p>\n
\u8c03\u8282\u6027T\u7ec6\u80de\u7684\u5173\u952e\u201c\u5f00\u5173\u201d<\/p>\n
\u4e0a\u4e16\u7eaa40\u5e74\u4ee3\uff0c\u4f5c\u4e3a\u201c\u66fc\u54c8\u987f\u8ba1\u5212\u201d\u7684\u4e00\u90e8\u5206\uff0c\u7f8e\u56fd\u6a61\u6811\u5cad\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u7684\u7814\u7a76\u4eba\u5458\u6b63\u5728\u7814\u7a76\u8f90\u5c04\u6548\u5e94\u3002\u5b9e\u9a8c\u4e2d\uff0c\u4ed6\u4eec\u5076\u7136\u53d1\u73b0\u4e86\u4e00\u4e2a\u81ea\u53d1\u7a81\u53d8\u7684\u96c4\u6027\u5c0f\u9f20\u54c1\u7cfb\uff0c\u8fd9\u4e9b\u5c0f\u9f20\u76ae\u80a4\u9cde\u5c51\u3001\u813e\u810f\u548c\u6dcb\u5df4\u7ed3\u5f02\u5e38\u80bf\u5927\uff0c\u4e14\u5bff\u547d\u6781\u77ed\u3002\u8fd9\u4e2a\u54c1\u7cfb\u88ab\u547d\u540d\u4e3a\u201cscurfy\u201d\uff08\u610f\u5473\u201c\u7c97\u7cd9\u7684\u201d\uff09\u3002<\/p>\n
\u5206\u5b50\u9057\u4f20\u5b66\u7814\u7a76\u663e\u793a\uff0cscurfy\u5c0f\u9f20\u7684\u75c5\u56e0\u662f\u5176\u514d\u75ab\u7cfb\u7edf\u53d1\u751f\u4e86\u201c\u5185\u4e71\u201d\uff0cT\u7ec6\u80de\u75af\u72c2\u653b\u51fb\u81ea\u8eab\u5668\u5b98\u3002\u7814\u7a76\u4eba\u5458\u8fd8\u786e\u5b9a\uff0c\u5bfc\u81f4\u8fd9\u4e00\u81f4\u547d\u75be\u75c5\u7684\u7a81\u53d8\u57fa\u56e0\u4f4d\u4e8eX\u67d3\u8272\u4f53\u4e0a\u3002<\/p>\n
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2001\u5e74\uff0c\u4ed6\u4eec\u5728\u300a\u81ea\u7136\u00b7\u9057\u4f20\u5b66\u300b\uff08Nature Genetics\uff09\u4e0a\u516c\u5e03\u4e86\u8fd9\u4e00\u91cd\u5927\u53d1\u73b0\u3002\u8fd9\u4e2a\u65b0\u53d1\u73b0\u7684\u57fa\u56e0\u4e0e\u4e00\u4e2a\u540d\u4e3a\u201c\u53c9\u5934\u6846\u201d\uff08forkhead box\uff09\u7684\u57fa\u56e0\u5bb6\u65cf\u76f8\u4f3c\uff0c\u4ed6\u4eec\u5c06\u5176\u547d\u540d\u4e3aFoxp3\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u4ed6\u4eec\u4e0e\u513f\u79d1\u533b\u751f\u5408\u4f5c\uff0c\u8bc1\u660e\u4e86\u4eba\u7c7b\u4e00\u79cd\u7f55\u89c1\u7684\u3001\u4e0escurfy\u5c0f\u9f20\u75c7\u72b6\u6781\u5176\u76f8\u4f3c\u7684X\u67d3\u8272\u4f53\u8fde\u9501\u81ea\u8eab\u514d\u75ab\u7efc\u5408\u5f81\uff08IPEX\uff09\uff0c\u6b63\u662f\u7531\u4eba\u7c7b\u540c\u6e90\u57fa\u56e0FOXP3\u7684\u7a81\u53d8\u6240\u5f15\u8d77\u7684\u3002<\/p>\n
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\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\uff0c1961\u5e74\u51fa\u751f\u3002\u7f8e\u56fd\u666e\u6797\u65af\u987f\u5927\u5b66\u535a\u58eb\u3002\u73b0\u4efb\u7f8e\u56fd\u897f\u96c5\u56fe\u7cfb\u7edf\u751f\u7269\u5b66\u7814\u7a76\u6240\u9ad8\u7ea7\u9879\u76ee\u7ecf\u7406\u3002<\/p>\n
\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u4ee3\u5c14\uff08Fred Ramsdell\uff09\uff0c1960\u5e74\u51fa\u751f\u30021987\u5e74\u83b7\u7f8e\u56fd\u52a0\u5dde\u5927\u5b66\u6d1b\u6749\u77f6\u5206\u6821\u535a\u58eb\u5b66\u4f4d\u3002\u73b0\u4efb\u7f8e\u56fd\u65e7\u91d1\u5c71Sonoma Biotherapeutics\u516c\u53f8\u79d1\u5b66\u987e\u95ee\u3002<\/p>\n
\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\uff0c1951\u5e74\u51fa\u751f\u30021976\u5e74\u548c1983\u5e74\u5206\u522b\u83b7\u5f97\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u533b\u5b66\u535a\u58eb\u548c\u54f2\u5b66\u535a\u58eb\u5b66\u4f4d\u3002\u73b0\u4efb\u65e5\u672c\u5927\u962a\u5927\u5b66\u514d\u75ab\u5b66\u524d\u6cbf\u7814\u7a76\u4e2d\u5fc3\u6770\u51fa\u6559\u6388\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
\u00b7\u4ece1940\u5e74\u4ee3scurfy\u5c0f\u9f20\u7684\u5076\u7136\u53d1\u73b0\uff0c\u52301960\u5e74\u4ee3\u7684\u80f8\u817a\u5207\u9664\u5b9e\u9a8c\uff0c\u518d\u52301990\u5e74\u4ee3\u7684\u5206\u5b50\u751f\u7269\u5b66\u7a81\u7834\uff0c\u5982\u4eca\uff0c\u4e16\u754c\u5404\u5730\u7684\u5b9e\u9a8c\u5ba4\u548c\u533b\u9662\u6b63\u5728\u5c06\u8fd9\u4e9b\u53d1\u73b0\u8f6c\u5316\u4e3a\u4e34\u5e8a\u5e94\u7528\u3002\u65e0\u8bba\u662f\u9971\u53d7\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u6298\u78e8\u7684\u60a3\u8005,\u8fd8\u662f\u7b49\u5f85\u5668\u5b98\u79fb\u690d\u7684\u75c5\u4eba,\u6291\u6216\u662f\u4e0e\u764c\u75c7\u6297\u4e89\u7684\u52c7\u58eb,\u90fd\u53ef\u80fd\u4ece\u8fd9\u4e09\u4f4d\u79d1\u5b66\u5bb6\u7684\u5de5\u4f5c\u4e2d\u83b7\u76ca\u3002 \u5317\u4eac\u65f6\u95f410\u67086\u65e517\u65f630\u5206\uff0c2025\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5728\u745e\u5178\u65af\u5fb7\u54e5\u5c14\u6469\u63ed\u6653\u3002\u5956\u9879\u6388\u4e88\u4e86\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\u3001\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u4ee3\u5c14\uff08Fred Ramsdell\uff09\u548c\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\uff0c\u4ee5\u8868\u5f70\u4ed6\u4eec\u5728\u5916\u5468\u514d\u75ab\u8010\u53d7\u65b9\u9762\u7684\u53d1\u73b0\u3002 \u8fd9\u4e09\u4f4d\u79d1\u5b66\u5bb6\u5171\u540c\u53d1\u73b0\u5e76\u5b9a\u4e49\u4e86\u514d\u75ab\u7cfb\u7edf\u4e2d\u7684\u5173\u952e\u201c\u7ef4\u548c\u90e8\u961f\u201d\u2014\u2014\u8c03\u8282\u6027T\u7ec6\u80de\uff08Regulatory T cells, Tregs\uff09\uff0c\u4e3a\u514d\u75ab\u5b66\u7814\u7a76\u5f00\u8f9f\u4e86\u4e00\u4e2a\u5168\u65b0\u7684\u9886\u57df\u3002\u8fd9\u4e00\u91cc\u7a0b\u7891\u5f0f\u7684\u53d1\u73b0\u4e0d\u4ec5\u6df1\u523b\u6539\u53d8\u4e86\u6211\u4eec\u5bf9\u81ea\u8eab\u514d\u75ab\u7cfb\u7edf\u5982\u4f55\u4fdd\u6301\u5e73\u8861\u7684\u7406\u89e3\uff0c\u66f4\u4e3a\u6cbb\u7597\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3001\u63d0\u5347\u764c\u75c7\u7597\u6548\u4ee5\u53ca\u9632\u6b62\u5668\u5b98\u79fb\u690d\u6392\u65a5\u53cd\u5e94\u5e26\u6765\u4e86\u65b0\u7684\u7b56\u7565\u3002 2025\u5e74\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u83b7\u5956\u8005\uff08\u5de6\u8d77\uff09\u739b\u4e3d\u00b7\u5e03\u4f26\u79d1\uff08Mary E. Brunkow\uff09\u3001\u5f17\u96f7\u5fb7\u00b7\u62c9\u59c6\u65af\u4ee3\u5c14\uff08Fred Ramsdell\uff09\u548c\u5742\u53e3\u5fd7\u6587\uff08Shimon Sakaguchi\uff09\u3002 \u201c\u4ed6\u4eec\u7684\u53d1\u73b0\u81f3\u5173\u91cd\u8981\uff0c\u4e0d\u4ec5\u6df1\u5316\u4e86\u6211\u4eec\u5bf9\u514d\u75ab\u7cfb\u7edf\u529f\u80fd\u7684\u7406\u89e3\uff0c\u8fd8\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u591a\u6570\u4e2a\u4f53\u4e0d\u4f1a\u60a3\u4e0a\u4e25\u91cd\u7684\u81ea\u8eab\u514d\u75ab\u75be\u75c5\u3002\u201d\u8bfa\u8d1d\u5c14\u59d4\u5458\u4f1a\u4e3b\u5e2dOlleK\u01cempe \u8868\u793a\u3002 \u514d\u75ab\u7cfb\u7edf\u7684\u201c\u7ef4\u548c\u90e8\u961f\u201d 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\u5742\u53e3\u5fd7\u6587\u575a\u4fe1\u514d\u75ab\u7cfb\u7edf\u4e2d\u5fc5\u7136\u5b58\u5728\u8fd9\u6837\u4e00\u652f\u201c\u7ef4\u548c\u90e8\u961f\u201d\uff0c\u5e76\u4e8e\u5176\u540e\u7684\u5341\u591a\u5e74\u4e2d\u8fdb\u884c\u4e86\u4e0d\u61c8\u5730\u7814\u7a76\u30021995\u5e74\uff0c\u4ed6\u5728\u300a\u514d\u75ab\u5b66\u6742\u5fd7\u300b\uff08The Journal of Immunology\uff09\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u91cc\u7a0b\u7891\u5f0f\u7684\u8bba\u6587\u3002\u4ed6\u53d1\u73b0\uff0c\u5728\u8f85\u52a9\u6027T\u7ec6\u80de\uff08\u901a\u5e38\u5e26\u6709CD4\u86cb\u767d\u6807\u5fd7\uff09\u4e2d\uff0c\u5b58\u5728\u4e00\u4e2a\u7279\u6b8a\u7684\u4e9a\u7fa4\uff0c\u5b83\u4eec\u8868\u9762\u4e0d\u4ec5\u6709CD4\uff0c\u8fd8\u9ad8\u6c34\u5e73\u8868\u8fbe\u4e00\u79cd\u540d\u4e3aCD25\u7684\u86cb\u767d\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u6b63\u662f\u8fd9\u7fa4T\u7ec6\u80de\u626e\u6f14\u7740\u6291\u5236\u514d\u75ab\u53cd\u5e94\u3001\u9632\u6b62\u81ea\u8eab\u653b\u51fb\u7684\u5173\u952e\u89d2\u8272\u3002 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