{"id":2538,"date":"2025-07-02T16:00:41","date_gmt":"2025-07-02T08:00:41","guid":{"rendered":"http:\/\/www.cscai.cn\/?p=2538"},"modified":"2025-11-06T21:01:03","modified_gmt":"2025-11-06T13:01:03","slug":"%e5%ba%b7%e5%ae%81%e6%9d%b0%e7%91%9e%e6%b6%85%e6%a7%83%e6%96%b0%e7%94%9f%ef%bc%9f","status":"publish","type":"post","link":"http:\/\/www.qlcxw.com.cn\/?p=2538","title":{"rendered":"\u5eb7\u5b81\u6770\u745e\u201c\u6d85\u69c3\u65b0\u751f\u201d\uff1f"},"content":{"rendered":"

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01<\/strong><\/em><\/p>\n

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 <\/p>\n

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02<\/strong><\/em><\/p>\n

\u518d\u6765\u4e00\u6b21\u7684\u673a\u4f1a<\/p>\n

 <\/p>\n

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2024\u5e749\u670829\u65e5\uff0c\u5eb7\u5b81\u6770\u745e\u53d1\u5e03\u516c\u544a\uff0c\u5c06HER2\u53cc\u8868\u4f4dADC\u836f\u7269JSKN003\u4e2d\u56fd\u5185\u5730\u5f00\u53d1\u3001\u9500\u552e\u7684\u6743\u76ca\uff0c\u6388\u6743\u7ed9\u77f3\u836f\u96c6\u56e2\u5b50\u516c\u53f8\u6d25\u66fc\u7279\u751f\u7269\u3002\u5eb7\u5b81\u6770\u745e\u5c06\u83b7\u5f974\u4ebf\u5143\u9996\u4ed8\u6b3e\uff0c\u6700\u9ad830.8\u4ebf\u5143\u7684\u9884\u4ed8\u6b3e\u548c\u91cc\u7a0b\u7891\u4ed8\u6b3e\u3002\u4f9d\u9760\u8fd9\u7b14\u5927\u989dBD\u4ea4\u6613\uff0c\u5eb7\u5b81\u6770\u745e\u5f97\u4ee5\u57282024\u5e74\u586b\u8865\u4e86\u4e8f\u7a7a\uff0c\u8f6c\u5411\u76c8\u5229\u3002<\/p>\n

\u77f3\u836f\u96c6\u56e2\u51fa\u624b\u5982\u6b64\u9614\u7ef0\uff0c\u4e00\u65b9\u9762\u5e94\u8be5\u662f\u770b\u5230\u4e86JSKN003\u57282024\u5e74ASCO\u4e0a\u7684\u6570\u636e\u516c\u544a\u7684\u7ed3\u679c\u3002\u5728HER2\u9633\u6027\u60a3\u8005\u4e2d\uff0c15\u4f8b\u4e73\u817a\u764c\u60a3\u8005\u7684ORR\u4e3a73.3%\uff1b\u5728HER2\u4f4e\u8868\u8fbe\u60a3\u8005\u4e2d\uff0c9\u4f8b\u4e73\u817a\u764c\u60a3\u8005\u7684ORR\u4e3a33.3%\u3002DS-8201\u9488\u5bf9\u4e0a\u8ff0\u7fa4\u4f53\u7684ORR\u5206\u522b\u4e3a54.5%\u300156.5%\u3002\u521d\u6b65\u6570\u636e\u663e\u793a\u5176\u5728\u7597\u6548\u4e0a\u4e0eDS-8201\u63a5\u8fd1\u3002\u5f53\u7136\uff0c\u8fd9\u5e76\u975e\u5934\u5bf9\u5934\u8bd5\u9a8c\u4e2d\uff0c\u60a3\u8005\u6570\u91cf\u4e5f\u592a\u5c11\uff0c\u56e0\u6b64\u542b\u91d1\u91cf\u5e76\u4e0d\u7b97\u592a\u9ad8\u3002\u60f3\u8981\u8bc1\u660e\u81ea\u5df1\u7684\u5b9e\u529b\uff0c\u8fd8\u8981\u62ff\u51fa\u66f4\u591a\u6570\u636e\u3002<\/p>\n

\u53e6\u4e00\u65b9\u9762\uff0c\u4e8c\u8005\u4e4b\u524d\u6709\u8fc7\u6210\u529f\u7684\u5408\u4f5c\uff0c\u5bf9\u5f7c\u6b64\u7b97\u662f\u77e5\u6839\u77e5\u5e95\u3002\u65e9\u57282021\u5e74\uff0c\u77f3\u836f\u96c6\u56e2\u5c31\u66fe\u4ee51.5\u4ebf\u5143\u9996\u4ed8\u6b3e\u5c06\u5eb7\u5b81\u6770\u745eKN026\u4e73\u817a\u764c\u3001\u80c3\u764c\u9002\u5e94\u75c7\u7684\u56fd\u5185\u6743\u76ca\u4e70\u4e86\u4e0b\u6765\u3002KN026\u662f\u4e00\u6b3eHER2\u53cc\u6297\uff0c\u80fd\u591f\u540c\u65f6\u7ed3\u5408HER2\u7684\u4e24\u4e2a\u975e\u91cd\u53e0\u8868\u4f4d\uff0c\u5bfc\u81f4HER2\u4fe1\u53f7\u963b\u65ad\u3002<\/p>\n

\u4eca\u5e744\u670830\u65e5\uff0c\u5eb7\u5b81\u6770\u745e\u5ba3\u5e03\uff0cKN026\u8054\u5408\u5316\u7597\u6cbb\u7597\u4e8c\u7ebf\u53ca\u4ee5\u540eHER2\u9633\u6027\u80c3\u764c\u7684II\/III\u671f\u4e34\u5e8a\uff0c\u671f\u4e2d\u5206\u6790\u663e\u793a\uff0c\u4e0e\u73b0\u6709\u6807\u51c6\u6cbb\u7597\u76f8\u6bd4\uff0cKN026\u8054\u5408\u5316\u7597\u663e\u8457\u6539\u5584\u60a3\u8005PFS\uff0c\u5e76\u5177\u6709OS\u83b7\u76ca\u8d8b\u52bf\u3002\u773c\u4e0b\uff0c\u8fd9\u6b3e\u4ea7\u54c1\u5df2\u7ecf\u6210\u4e86\u5eb7\u5b81\u6770\u745e\u7ba1\u7ebf\u4e2d\u6700\u503c\u5f97\u671f\u5f85\u7684\u4ea7\u54c1\u3002\u77f3\u836f\u96c6\u56e2\u82b1\u91cd\u91d1\u4e70\u4e0b\u7684JSKN003\uff0c\u6b63\u662f\u5eb7\u5b81\u6770\u745e\u57fa\u4e8eKN026\u7814\u53d1\u7684HER2\u53cc\u6297ADC\u3002\u8fd9\u4e5f\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u8bc1\u660e\u4e86\uff0c\u77f3\u836f\u96c6\u56e2\u5bf9\u4e8eKN026\u7684\u671f\u5f85\u3002<\/p>\n

\u9664\u4e0a\u8ff0\u4ea4\u6613\u4e4b\u5916\u30022024\u5e746\u6708\uff0c\u5eb7\u5b81\u6770\u745e\u8fd8\u4e0eArriVent\u516c\u53f8\u8fbe\u6210\u5408\u4f5c\uff0c\u5229\u7528\u81ea\u5bb6ADC\u5e73\u53f0\uff0c\u5171\u540c\u7814\u53d1ADC\u65b0\u836f\uff0c\u518d\u52a0\u4e0a2024\u5e74\u521d\u4e0eGlenmark\u7684PD-L1\u5408\u4f5c\u3002\u4e09\u7b14BD\u4ea4\u6613\u6b3e\u7684\u5230\u8d26\uff0c\u8ba9\u5eb7\u5b81\u6770\u745e\u5f97\u4ee5\u9996\u6b21\u76c8\u5229\uff0c\u4e00\u626b\u4e34\u5e8a\u5931\u8d25\u7684\u9634\u973e\u3002<\/p>\n

03<\/strong><\/em><\/p>\n

\u4e00\u573a\u672a\u7adf\u4e4b\u6218<\/p>\n

 <\/p>\n

\u66d9\u5149\u521d\u73b0\u80cc\u540e\uff0c\u6295\u8d44\u8005\u4ecd\u5fc5\u987b\u6b63\u89c6\u5eb7\u5b81\u6770\u745e\u524d\u8def\u4f9d\u7136\u56f0\u96be\u91cd\u91cd\u3002\u5e02\u573a\u7684\u4e0b\u4e00\u4e2a\u5173\u6ce8\u70b9\uff0c\u6b63\u5728\u4e8e\u5eb7\u5b81\u6770\u745e\u80fd\u5426\u4ece\u6293\u4f4fBD\u5e26\u6765\u7684\u673a\u4f1a\uff0c\u987a\u5229\u4ece\u9636\u6bb5\u6027\u76c8\u5229\u8fc8\u5411\u6301\u7eed\u4ef7\u503c\u521b\u9020\uff1f<\/p>\n

\u76ee\u524d\uff0c\u5eb7\u5b81\u6770\u745e\u7ba1\u7ebf\u4e2d\u5b58\u5728BD\u6f5c\u529b\u7684\u4ea7\u54c1\u5e76\u4e0d\u591a\uff0c\u6700\u5177\u5e0c\u671b\u7684\u4e5f\u5c31\u662fHER3\/TROP2\u53cc\u6297JSKN016\u3002\u4f46HER3\u3001TROP2 ADC\u836f\u7269\u76ee\u524d\u8fdb\u5c55\u5e76\u4e0d\u7b97\u592a\u987a\u5229\uff0c\u8fd9\u4e00\u4ea7\u54c1\u53c8\u5904\u4e8e\u4e34\u5e8a\u65e9\u671f\u9636\u6bb5\uff0c\u76f8\u5173\u6570\u636e\u8f83\u5c11\uff0c\u8fd8\u5b58\u5728\u7740\u6781\u5927\u7684\u4e0d\u786e\u5b9a\u6027\u3002\u5982\u679c\u540e\u7eed\u5eb7\u5b81\u6770\u745e\u6ca1\u6709\u5176\u4ed6\u4ea7\u54c1\u8bde\u751fBD\u4ea4\u6613\uff0c\u90a3\u4e48\u5728\u4e00\u6b21\u6027\u6536\u5165\u6d88\u8017\u6b86\u5c3d\u540e\uff0c\u5eb7\u5b81\u6770\u745e\u53ef\u80fd\u4f1a\u518d\u5ea6\u9677\u5165\u4e8f\u635f\u7684\u56f0\u5883\u4e2d\u3002<\/p>\n

\u4ece\u4ea7\u54c1\u7aef\u6765\u770b\uff0c\u5eb7\u5b81\u6770\u745e\u76ee\u524d\u4ec5\u6709\u4e00\u6b3ePD-1\u6069\u6c83\u5229\u5355\u6297\u83b7\u6279\u4e0a\u5e02\u3002\u867d\u7136\u5176\u662f\u76ae\u4e0b\u6ce8\u5c04\u5236\u5242\uff0c\u6709\u7740\u8f83\u597d\u7684\u4f9d\u4ece\u6027\uff0c\u4f46\u8fd9\u4e24\u5e74\u56fd\u5185PD-1\/L1\u624e\u5806\u4e0a\u5e02\uff0c\u5e02\u573a\u7ade\u4e89\u5df2\u7ecf\u767d\u70ed\u5316\uff0c\u518d\u52a0\u4e0a\u533b\u4fdd\u8c08\u5224\u964d\u4ef7\u7684\u51b2\u51fb\uff0c\u6069\u6c83\u5229\u5355\u6297\u9500\u552e\u5df2\u7ecf\u653e\u7f13\u3002\u8d22\u62a5\u663e\u793a\uff0c2024\u5e74\u5176\u6536\u5165\u4e3a1.59\u4ebf\u5143\uff0c\u800c2023\u5e74\u540c\u671f\u8fd9\u4e00\u6570\u5b57\u4e3a1.95\u4ebf\u5143\uff0c\u540c\u6bd4\u4e0b\u964d18%\u3002<\/p>\n

\u540c\u65f6\uff0c\u6069\u6c83\u5229\u5355\u6297\u60f3\u8981\u51b2\u51fb\u6d77\u5916\u5e02\u573a\u7684\u5e0c\u671b\uff0c\u57fa\u672c\u5df2\u7ecf\u7834\u706d\u30022024\u5e74\uff0c\u7531\u4e8e\u4e34\u5e8a\u5173\u952e\u8bd5\u9a8c\u672a\u8fbe\u5230\u4e3b\u8981\u7ec8\u70b9\uff0c\u5eb7\u5b81\u6770\u745e\u7684\u7f8e\u56fd\u5408\u4f5c\u4f19\u4f34\u8868\u793a\uff0c\u5c06\u7ec8\u6b62\u5bf9\u6069\u6c83\u5229\u5355\u6297\u7684\u8fdb\u4e00\u6b65\u5f00\u53d1\u3002<\/p>\n

\u5728\u7814\u7ba1\u7ebf\u65b9\u9762\uff0c\u5eb7\u5b81\u6770\u745e\u8fdb\u5ea6\u6700\u5feb\u7684\u4ea7\u54c1\u4e3aKN026\u3002\u5eb7\u5b81\u6770\u745e\u6b64\u524d\u9884\u8ba1\uff0c\u5c06\u4e8e2025\u5e74\u63d0\u4ea4\u5176\u4e0a\u5e02\u7533\u8bf7\u3002\u636e\u4e1c\u5434\u8bc1\u5238\u9884\u6d4b\uff0cKN026\u7684\u80c3\u764c\u9002\u5e94\u75c7\u9884\u8ba1\u57282026\u5e74\u5e95\u83b7\u6279\u4e0a\u5e02\u3002\u7136\u800c\uff0c\u4e00\u7ebf\u6cbb\u7597HER2\u9633\u6027\u4e73\u817a\u764c\u624d\u662fKN026\u771f\u6b63\u7684\u91cd\u5934\u620f\uff0c\u800c\u8fd9\u4e00\u9002\u5e94\u75c7\u9884\u8ba1\u57282027\u5e74\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n

\u4f46\u4e73\u817a\u764c\u9886\u57df\u6709\u6700\u5f3aADC\u836f\u7269DS-8201\u5728\u524d\uff0cKN026\u80fd\u6709\u591a\u5927\u7684\u5e02\u573a\u4efd\u989d\u4ecd\u9700\u753b\u4e0a\u4e00\u4e2a\u95ee\u53f7\u3002\u66f4\u4f55\u51b5\uff0cKN026\u7684\u56fd\u5185\u9500\u552e\u6743\u76ca\u5df2\u7ecf\u5356\u7ed9\u4e86\u77f3\u836f\u96c6\u56e2\u3002\u8fd9\u610f\u5473\u7740\uff0c\u5373\u4fbfKN026\u6210\u529f\u4e0a\u5e02\u4e0a\u5e02\u9500\u552e\uff0c\u5eb7\u5b81\u6770\u745e\u4e5f\u53ea\u80fd\u62ff\u5230\u5176\u4e2d\u4e00\u5c0f\u90e8\u5206\u9500\u552e\u5206\u6210\u3002<\/p>\n

\u603b\u4f53\u800c\u8a00\uff0c\u5eb7\u5b81\u6770\u745e\u867d\u7136\u5b8c\u6210\u4e86\u60ca\u9669\u7684\u201c\u6d85\u69c3\u65b0\u751f\u201d\uff0c\u4f46\u4ecd\u7136\u6ca1\u6709\u5f7b\u5e95\u4e0a\u5cb8\uff0c\u672a\u6765\u8fd8\u5b58\u5728\u7740\u5f88\u5927\u7684\u4e0d\u786e\u5b9a\u6027\u3002\u53ef\u516c\u53f8\u7ba1\u7406\u5c42\u4f3c\u4e4e\u6ca1\u6709\u592a\u591a\u7684\u8010\u5fc3\uff0c\u5728\u9996\u5ea6\u5b9e\u73b0\u76c8\u5229\uff0c\u516c\u53f8\u80a1\u4ef7\u5f00\u59cb\u56de\u6696\u4e4b\u9645\uff0c\u7ba1\u7406\u5c42\u4fbf\u8feb\u4e0d\u53ca\u5f85\u7684\u5f00\u59cb\u5957\u73b0\u30022025\u5e746\u67085\u65e5\uff0c\u5eb7\u5b81\u6770\u745e\u516c\u5e03\uff0c\u63a7\u80a1\u80a1\u4e1c\u4ee5\u6bcf\u80a1\u80a1\u4efd8.05\u6e2f\u5143\u7684\u4ef7\u683c\u6210\u529f\u914d\u552e\uff0c\u5957\u73b0\u7ea61.175\u4ebf\u6e2f\u5143\u3002<\/p>\n

\u5bf9\u4e8e\u5eb7\u5b81\u6770\u745e\u7684\u672a\u6765\uff0c\u7ba1\u7406\u5c42\u4f3c\u4e4e\u5df2\u7ecf\u7528\u5b9e\u9645\u884c\u52a8\u7ed9\u51fa\u4e86\u201c\u5fc3\u4e2d\u7684\u7b54\u6848\u201d\u3002<\/p>\n

\u00b7 \u9776\u70b9\u683c\u5c40 \u00b7<\/p>\n

PD-1\u9776\u70b9\u00a0|\u00a0TIGIT\u9776\u70b9\u00a0|\u00a0Claudin18.2\u9776\u70b9<\/p>\n

BCR-ABL\u9776\u70b9\u00a0|\u00a0PCSK9\u9776\u70b9\u00a0|\u00a0Bcl-2\u9776\u70b9<\/p>\n

GLP-1\u9776\u70b9\u00a0|\u00a0CDK4\/6\u9776\u70b9\u00a0|\u00a0CD20\u9776\u70b9<\/p>\n

EGFR\u9776\u70b9\u00a0|\u00a0KRAS\u9776\u70b9\u00a0|\u00a0CD47\u9776\u70b9<\/p>\n

c-MET\u9776\u70b9\u00a0|\u00a0ALK\u9776\u70b9<\/p>\n

\u00b7 MNC\u89c2\u5bdf \u00b7<\/p>\n

\u793c\u6765\u00a0|\u00a0\u9ed8\u6c99\u4e1c\u00a0|\u00a0\u8bfa\u548c\u8bfa\u5fb7\u00a0|\u00a0\u5f3a\u751f<\/p>\n

\u963f\u65af\u5229\u5eb7\u00a0|\u00a0\u8bfa\u534e\u00a0|\u00a0\u8f89\u745e\u00a0|\u00a0\u7f57\u6c0f<\/p>\n

\u827e\u4f2f\u7ef4\u00a0|\u00a0GSK\u00a0|\u00a0\u5409\u5229\u5fb7\u00a0|\u00a0\u62dc\u8033<\/p>\n

\u798f\u6cf0\u5236\u836f\u00a0|\u00a0Moderna\u00a0 |\u00a0\u5b89\u8fdb\u00a0|\u00a0\u94f6\u4f11\u7279<\/p>\n

\u5fb7\u5eb7\u533b\u7597\u00a0|\u00a0\u53f2\u8d5b\u514b\u00a0|\u00a0Illumina<\/p>\n

\u00b7 \u4ea7\u4e1a\u5730\u56fe \u00b7<\/p>\n

\u767e\u6d4e\u795e\u5dde\u00a0|\u00a0\u6052\u745e\u533b\u836f\u00a0|\u00a0\u541b\u5b9e\u751f\u7269\u00a0|\u00a0\u4fe1\u8fbe\u751f\u7269<\/p>\n

\u518d\u9f0e\u533b\u836f\u00a0|\u00a0\u590d\u5b8f\u6c49\u9716\u00a0|\u00a0\u5148\u58f0\u836f\u4e1a\u00a0|\u00a0\u5eb7\u65b9\u751f\u7269<\/p>\n

\u836f\u660e\u5eb7\u5fb7\u00a0|\u00a0\u836f\u660e\u751f\u7269\u00a0|\u00a0\u8d1d\u8fbe\u836f\u4e1a\u00a0|\u00a0\u8bfa\u8bda\u5065\u534e<\/p>\n

\u4e9a\u76db\u533b\u836f\u00a0|\u00a0\u8fea\u54f2\u533b\u836f\u00a0| \u8363\u660c\u751f\u7269\u00a0|\u00a0\u57fa\u77f3\u836f\u4e1a<\/p>\n

\u8bfa\u8f89\u5065\u5eb7\u00a0|\u00a0\u8fc8\u745e\u533b\u7597\u00a0|\u00a0\u8054\u5f71\u533b\u7597\u00a0|\u00a0\u534e\u5927\u667a\u9020<\/p>\n

\u7231\u5c14\u773c\u79d1\u00a0|\u00a0\u65f6\u4ee3\u5929\u4f7f\u00a0|\u00a0\u4e9a\u8679\u533b\u836f\u00a0|\u00a0\u5eb7\u5b81\u6770\u745e<\/p>\n

\u767e\u6d0b\u533b\u836f\u00a0|\u00a0\u8baf\u98de\u533b\u7597\u00a0|\u00a0\u5fae\u521b\u533b\u7597\u00a0|\u00a0\u798f\u745e\u80a1\u4efd<\/p>\n

\u4eac\u4e1c\u5065\u5eb7\u00a0|\u00a0\u7f8e\u56e2\u533b\u836f\u00a0|\u00a0\u6676\u6cf0\u79d1\u6280\u00a0|\u00a0\u82f1\u77fd\u667a\u80fd<\/p>\n

\u91d1\u65af\u745e\u751f\u7269\u00a0|\u00a0\u4f20\u5947\u751f\u7269\u00a0|\u00a0\u534e\u4e1c\u533b\u836f\u00a0|\u00a0\u4e91\u9876\u65b0\u8000<\/p>\n

 <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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