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left;\"><strong>\u636e\u5f17\u82e5\u65af\u7279\u6c99\u5229\u6587\u62a5\u544a\uff0c2018\u5e74\u6211\u56fd\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u60a3\u8005\u91cf\u4e3a587.8\u4e07\uff0c2023\u5e74\u540e\u4eba\u6570\u7a81\u7834600\u4e07\uff0c\u9884\u8ba1\u52302030\u5e74\u60a3\u8005\u4eba\u6570\u5c06\u589e\u81f3640.9\u4e07\uff0c\u5e74\u590d\u5408\u589e\u957f\u7387\u4ec50.8%\u3002\u5e02\u573a\u6269\u5bb9\u901f\u5ea6\u8ddf\u4e0d\u4e0a\u65b0\u836f\u4e0a\u5e02\u901f\u5ea6\uff0c\u72fc\u591a\u8089\u5c11\u3001\u5e02\u573a\u5185\u5377\uff0c\u4ece\u4e1a\u8005\u65e5\u5b50\u81ea\u7136\u4e0d\u4f1a\u591a\u597d\u8fc7\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u518d\u770b\u8fc8\u5229\u8212\u3001\u8fc8\u536b\u5065\uff0c\u4e3a\u5730\u8212\u5355\u6297\u751f\u7269\u7c7b\u4f3c\u836f\uff0c\u5206\u522b\u7528\u4e8e\u9aa8\u6298\u9ad8\u98ce\u9669\u7684\u7edd\u7ecf\u540e\u5987\u5973\u7684\u9aa8\u8d28\u758f\u677e\u75c7\u6cbb\u7597\u53ca\u5b9e\u4f53\u7624\u9aa8\u8f6c\u79fb\u6cbb\u7597\u30022023\u5e74\uff0c\u8fc8\u5229\u8212\u5730\u8212\u5355\u6297\u53d1\u8d27245341\u652f\uff0c\u65b0\u589e\u51c6\u5165\u533b\u96621137\u5bb6\u3002\u622a\u81f32024\u5e74\u672b\u7d2f\u8ba1\u5b8c\u6210\u53d1\u8d27329815\u652f\uff0c\u7d2f\u8ba1\u51c6\u5165\u533b\u96621857\u5bb6\u3002\u4ee5\u6b64\u8ba1\u7b97\uff0c2024\u5e74\u8fc8\u5229\u8212\u53d1\u8d27\u91cf\u4e5f\u4ec5\u67098\u4e07\u591a\u652f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\"><strong>2023\u5e74\u4e00\u5b63\u62a5\u4e2d\uff0c\u8fc8\u5a01\u751f\u7269\u66fe\u9884\u6d4b\u5168\u5e74\u8fc8\u5229\u8212\u3001\u541b\u8fc8\u5eb7\u4e24\u6b3e\u4ea7\u54c1\u53ef\u5408\u8ba1\u5b9e\u73b0\u9500\u552e\u6536\u5165\u4e0d\u4f4e\u4e8e4.3\u4ebf\u5143\u3002\u7136\u6700\u7ec8\u8fdc\u4e0d\u53ca\u8be5\u76ee\u6807\uff0c\u5408\u8ba1\u4ec54208.96\u4e07\u5143\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u9664\u4e86\u591a\u6b3e\u4ea7\u54c1\u5546\u4e1a\u5316\u4e0d\u53ca\u9884\u671f\uff0c\u5728\u7814\u8fdb\u7a0b\u4e5f\u51fa\u73b0\u6ce2\u6f9c\u30022024\u5e742\u670824\u65e5\uff0c\u8fc8\u5a01\u751f\u7269\u53ca\u5168\u8d44\u5b50\u516c\u53f8\u6cf0\u5eb7\u751f\u7269\u4e0e\u626c\u5b50\u6c5f\u836f\u4e1a\u5168\u8d44\u5b50\u516c\u53f8\u6d77\u535a\u751f\u7269\u5c319MW1111\uff08\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\u6ce8\u5c04\u6db2\uff09\u9879\u76ee\u7ec8\u6b62\u5408\u4f5c\uff0c\u7b7e\u7f72\u300a\u534f\u5546\u89e3\u9664\u534f\u8bae\u300b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u516c\u5f00\u8d44\u6599\u663e\u793a\uff0c9MW1111\u662f\u4e00\u6b3e\u7531\u8fc8\u5a01\u751f\u7269\u81ea\u4e3b\u7814\u53d1\u7684\u521b\u65b0\u91cd\u7ec4\u4eba\u6e90\u5316\u6297PD-1\u5355\u514b\u9686\u6297\u4f53\uff0c\u4f5c\u4e3a\u521b\u65b0\u836f\u8d5b\u9053\u7684\u660e\u661f\u9776\u70b9\u3002PD-1\u5df2\u662f\u521b\u65b0\u836f\u4f01\u7684\u201c\u5175\u5bb6\u5fc5\u4e89\u4e4b\u5730\u201d\uff0c\u662f\u4e1a\u5185\u516c\u8ba4\u7684\u201c\u5377\u738b\u201d\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u5982IQVIA\u521a\u521a\u53d1\u5e03\u7684\u300a2024\u4e0b\u534a\u5e74\u4e2d\u56fdPD-(L)1\u5e02\u573a\u56de\u987e\u300b\u663e\u793a\uff0c\u76ee\u524d\u56fd\u5185\u5e02\u573a\u5df2\u96c6\u805a23\u6b3e\u201c\u5200\u5251\u201d\uff0c\u5305\u62ec15\u6b3ePD-1\uff08\u5176\u4e2d2\u4e2a\u4e3a\u53cc\u6297CTLA4\/PD-1\u548c1\u4e2aVEGF-A\/PD-1\uff09\u4e0e8\u6b3ePD-L1\u77ed\u5175\u76f8\u63a5\uff0c\u8986\u76d6\u5341\u4f59\u4e2a\u7624\u79cd\u53ca\u6cdb\u7624\u79cd\u6218\u573a\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u9762\u5bf9\u5de8\u5927\u7ade\u4e89\u538b\u529b\uff0c9MW1111\u9879\u76ee\u53eb\u505c\u4e0d\u8db3\u4e3a\u5947\u3002\u8003\u9a8c\u5728\u4e8e\uff0c\u968f\u7740\u7ec8\u6b62\u5408\u4f5c\uff0c\u8fc8\u5a01\u751f\u7269\u9700\u9000\u56de\u524d\u671f\u9884\u4ed8\u53ca\u5206\u644a\u7814\u53d1\u8d39\u7528\uff0c\u516c\u53f8\u9884\u8ba1\u4f1a\u5bf92023\u5e74\u5ea6\u51cf\u5c11\u7a0e\u524d\u5229\u6da6\u7ea61.1\u4ebf\u5143\u3002\u8fd9\u5bf9\u672c\u5c31\u6df1\u9677\u4e8f\u635f\u6ce5\u6f6d\u7684\u8fc8\u5a01\u800c\u8a00\u65e0\u7591\u96ea\u4e0a\u52a0\u971c\u3002\u4f55\u4ee5\u9519\u4ed8\u8bef\u5224\uff0c\u65e9\u671f\u5e02\u573a\u8c03\u7814\u3001\u8d5b\u9053\u5361\u4f4d\u662f\u5426\u7cbe\u51c6\u5462\uff1f<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u68b3\u7406\u76ee\u524d\u7684\u50a8\u5907\u7ba1\u7ebf\uff0cNectin-4 ADC 9MW2921\u4e0d\u5f97\u4e0d\u63d0\u30022024\u5e748\u6708\uff0c\u8fc8\u5a01\u751f\u7269\u542f\u52a8\u4e86\u5173\u952eIII\u671f\u4e34\u5e8a\u7814\u7a76\uff0c\u6cbb\u7597\u542b\u94c2\u5316\u7597\u5931\u8d25\u7684\u590d\u53d1\u6216\u8f6c\u79fb\u6027\u5bab\u9888\u764c\u3002\u636e\u6089\u8fd9\u4e5f\u662f\u5168\u7403\u9996\u6b3e\u5728\u5bab\u9888\u764c\u9002\u5e94\u75c7\u8fdb\u5165III\u671f\u4e34\u5e8a\u7814\u7a76\u7684Nectin-4ADC\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u4ece\u7597\u6548\u6570\u636e\u770b\uff0c\u6839\u636e9MW2821\u5355\u836f\u5728\u665a\u671f\u5c3f\u8def\u4e0a\u76ae\u764c\u540e\u7ebf\u60a3\u8005\u4e2d\u7684\u6570\u636e\uff0c62.2%\u7684ORR\u548c91.9%\u7684DCR\u5747\u9ad8\u4e8e\u5df2\u4e0a\u5e02\u7684Padcev\u6069\u8bfa\u5355\u6297\u3002\u57fa\u4e8e\u8f83\u51fa\u8272\u7684\u4e34\u5e8a\u8868\u73b0\uff0c\u5176\u88ab\u8ba4\u4e3a\u662f\u8fc8\u5a01\u751f\u7269\u6700\u5177\u4ef7\u503c\uff0c\u4e14\u6700\u6709\u5e0c\u671bBD\u6388\u6743\u7684ADC\u7ba1\u7ebf\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u4e0d\u8fc7\uff0c\u9664\u4e86\u6069\u8bfa\u5355\u6297\uff0c\u76ee\u524d\u56fd\u5185\u521b\u65b0\u836f\u4f01\u4e2d\u767e\u5965\u6cf0\u3001\u6052\u745e\u533b\u836f\u3001\u79d1\u4f26\u535a\u6cf0\u751f\u7269\u2014B\u3001\u77f3\u836f\u96c6\u56e2\u5747\u5728Nectin-4\u9776\u70b9\u4e0a\u8fdb\u884c\u4e86\u4ea7\u54c1\u5e03\u5c40\u3002\u5f3a\u654c\u73af\u4f3a\u4e2d\uff0c\u672a\u6765\u8fc8\u5a01\u751f\u72699MW2821\u7684\u5546\u4e1a\u5316\u4e4b\u8def\u4e5f\u662f\u673a\u9047\u4e0e\u6311\u6218\u5e76\u5b58\u3002\u80fd\u5426\u4e0d\u8d1f\u671f\u8bb8\uff0c\u4e3a\u4e1a\u7ee9\u6551\u8d4e\u3001\u6446\u8131\u4e8f\u6001\u5e26\u6765\u66d9\u5149\u662f\u4e00\u5927\u770b\u70b9\u3002\u80cc\u540e\u79bb\u4e0d\u5f00\u9ad8\u8d28\u9ad8\u6548\u7684\u7efc\u5408\u7814\u53d1\u80fd\u529b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><strong>3<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u4e8c\u6b21\u4e0a\u5e02\u9047\u201c\u9ed1\u5929\u9e45\u201d<\/strong><\/p>\n<p style=\"text-align: center;\"><strong>\u5168\u7403\u5316\u6218\u7565\u4f55\u53bb\u4ece<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u521b\u65b0\u836f\u7684\u5b75\u5316\u662f\u4e00\u573a\u65f6\u95f4\u8d5b\u8dd1\u3001\u8d28\u6548\u6bd4\u62fc\uff0c\u9700\u8981\u8f83\u5145\u88d5\u7684\u8d44\u91d1\u5e95\u76d8\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u4e3a\u4e86\u62d3\u5bbd\u878d\u8d44\u6e20\u9053\uff0c<strong>2025\u5e743\u670830\u65e5\uff0c\u8fc8\u5a01\u751f\u7269\u516c\u544a\u79f0\uff0c\u62df\u5411\u4e2d\u56fd\u94f6\u884c\u95f4\u5e02\u573a\u4ea4\u6613\u5546\u534f\u4f1a\u7533\u8bf7\u6ce8\u518c\u53d1\u884c\u89c4\u6a21\u4e0d\u8d855\u4ebf\u5143\uff08\u542b5\u4ebf\u5143\uff09\u7684\u5b9a\u5411\u503a\u52a1\u878d\u8d44\u5de5\u5177\uff0c\u52df\u8d44\u7528\u9014\u4e3a\u507f\u8fd8\u6709\u606f\u8d1f\u503a\u3001\u9879\u76ee\u5efa\u8bbe\u3001\u8865\u5145\u6d41\u52a8\u8d44\u91d1\u7b49\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u4e142024\u5e74\u4ee5\u6765\uff0c\u8fc8\u5a01\u751f\u7269\u4e24\u6b21\u8c03\u589e\u6388\u4fe1\u989d\u5ea6\uff0c\u4ece23\u4ebf\u5143\u589e\u81f362\u4ebf\u5143\u3002\u4f46\u968f\u7740\u8d44\u4ea7\u8d1f\u503a\u7387\u7684\u6301\u7eed\u6500\u5347\uff0c\u516c\u53f8\u9700\u66f4\u591a\u65e0\u606f\u878d\u8d44\u6765\u8865\u5145\u8d44\u672c\u3002\u4e3a\u6b642025\u5e741\u67086\u65e5\uff0c\u8fc8\u5a01\u5411\u6e2f\u4ea4\u6240\u63d0\u4ea4\u4e86\u4e0a\u5e02\u7533\u8bf7\u3002\u65e8\u5728\u63d0\u5347\u56fd\u9645\u5316\u6c34\u5e73\u3001\u589e\u5f3a\u8d44\u672c\u5b9e\u529b\uff0c\u4e3a\u672a\u6765\u6269\u5f20\u548c\u7814\u53d1\u6295\u5165\u63d0\u4f9b\u8d44\u91d1\u652f\u6301\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\u4e0a\u5347\u5230\u884c\u4e1a\u89c6\u89d2\uff0c\u8d74\u6e2f\u4e0a\u5e02\u4e5f\u662f\u533b\u836f\u4f01\u4e1a\u505a\u5927\u505a\u5f3a\u7684\u4e00\u79cd\u8d8b\u52bf\u30022024\u5e74\u4ee5\u6765\uff0c\u5eb7\u4e50\u536b\u58eb\u3001\u767e\u5229\u5929\u6052\u3001\u6052\u745e\u533b\u836f\u76f8\u7ee7\u5b98\u5ba3\u5c06\u5728\u6e2f\u4ea4\u6240\u4e0a\u5e02\u3002\u622a\u81f32024\u5e74\u672b\uff0c\u5df2\u670919\u5bb6\u751f\u7269\u533b\u836f\u4e0a\u5e02\u516c\u53f8\u5b9e\u73b0\u4e86A\u3001H\u4e24\u5730\u540c\u65f6\u4e0a\u5e02\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: 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