{"id":1463,"date":"2025-06-13T21:00:09","date_gmt":"2025-06-13T13:00:09","guid":{"rendered":"http:\/\/www.cscai.cn\/?p=1463"},"modified":"2025-11-07T16:09:55","modified_gmt":"2025-11-07T08:09:55","slug":"%e5%ba%b7%e6%96%b9%e4%bd%95%e4%bb%a5%e8%87%b3%e6%ad%a4%ef%bc%9f","status":"publish","type":"post","link":"http:\/\/www.qlcxw.com.cn\/?p=1463","title":{"rendered":"\u5eb7\u65b9\u4f55\u4ee5\u81f3\u6b64\uff1f"},"content":{"rendered":"

Summit\u8dcc\u5f97\u4e0d\u51a4\u3002<\/p>\n

\u5f00\u59cb\u65f6\uff0c\u6211\u4eec\u9700\u8981\u5398\u6e05\u4e24\u4e2a\u57fa\u7840\u6982\u5ff5\u3002\u4e00\u662fAK112\u5934\u5bf9\u5934\u6218\u80dcK\u836f\uff0c\u5e94\u8be5\u4ee5MRCT\uff08\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6570\u636e\u4e3a\u51c6\uff0c\u4ee5OS\u4e3a\u80bf\u7624\u7597\u6548\u8bc4\u4ef7\u7684\u91d1\u6807\u51c6\uff08\u8be6\u89c12024\u5e7412\u6708\u300a\u5eb7\u65b9\u64e6\u8fb9\u300b\uff09\uff1b\u4e8c\u662fSummit\u7684\u5e02\u503c\u5927\u53a6\uff0c\u4ee5\u53ca\u5eb7\u65b9\u751f\u7269\u7684\u5927\u90e8\u5206\u5e02\u503c\uff0c\u90fd\u662f\u5efa\u7acb\u5728HARMONi-3\u3001HARMONi-7\u4e24\u9879AK112\u5934\u5bf9\u5934K\u836f\u7684MRCT\u4e4b\u4e0a\uff0c\u4e2d\u56fd\u5355\u533a\u57df\u8bd5\u9a8cHARMONi-2\u4e0d\u80fd\u4e00\u9524\u5b9a\u97f3\uff0c\u53ea\u662f\u524d\u77bb\u6027\u6307\u6807\u3002<\/p>\n

\u4e8e\u662f\uff0c\u5d29\u584c\u7684\u903b\u8f91\u4f20\u5bfc\u975e\u5e38\u4e1d\u6ed1\u3002HARMONi-2\u83b7\u5f97OS\u548cPFS\u53cc\u7ec8\u70b9\u663e\u8457\uff0c\u65e0\u53ef\u4e89\u8bae\uff0c\u4f46OS\u7684HR\u4e3a0.777\uff0c\u843d\u57280.8\u7684\u9608\u503c\u9644\u8fd1\u3002\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(ASCO)\u5728NSCLC\u8bd5\u9a8c\u4e2d\u5b9a\u4e49HR\u4f4e\u4e8e0.8\u7684\u8bd5\u9a8c\u624d\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002<\/p>\n

\u5728\u6709\u5229\u6761\u4ef6\u4e0b\uff0cHR\u4ecd\u7136\u903c\u8fd1\u9608\u503c\u3002\u8003\u8651\u5230\u6d77\u5916\u4e34\u5e8a\u771f\u6b63\u5177\u6709\u6311\u6218\u6027\uff0cOS HR<0.8\u96be\u5ea6\u9661\u589e\uff0c\u98ce\u9669\u655e\u53e3\u66b4\u9732\u4e86\u3002<\/p>\n

HARMONi-3\u9884\u8ba14\u5e74\u5de6\u53f3\u5b8c\u6210\u4e34\u5e8a\uff0c\u5eb7\u65b9\u751f\u7269\u5c06\u5728\u8f83\u957f\u65f6\u95f4\u4e0e\u4e0d\u786e\u5b9a\u6027\u6346\u7ed1\uff0c\u53bb\u5e74\u6709524\u66b4\u8dcc\uff0c\u4eca\u540e\u5462\uff1f\u5176\u5b9e\uff0c\u4f5c\u4e3a\u4e00\u5bb6\u9886\u5148\u7684Biopharma\uff0c\u672c\u6709\u575a\u5982\u78d0\u77f3\u7684\u9884\u671f\uff0c\u4f55\u4ee5\u81f3\u6b64\uff1f<\/p>\n

\n

01\u00a0<\/strong>
\n<\/strong>\u98ce\u9669\u655e\u53e3<\/p>\n

\u9ad8\u76db\u62a5\u544a\u9884\u6d4b\uff0cAK112\u57282041\u5e74\u5cf0\u503c\u9500\u552e\u7ea6530\u4ebf\u7f8e\u5143\uff0c\u5e76\u7ed9\u4e88Summit\u00a0\u4f30\u503c300\u4ebf\u7f8e\u5143\u3002<\/p>\n

\u9ad8\u76db\u4e0d\u8822\uff0c\u5374\u662f\u771f\u7684\u574f\uff0c\u8d44\u672c\u505a\u5c40\u7684\u9ad8\u624b\u3002<\/p>\n

<\/p>\n

HARMONI-2<\/b>\u7814\u7a76\u60a3\u8005\u57fa\u7ebf\u72b6\u51b5 \u00a0 \u6570\u636e\u6765\u6e90\uff1aWCLC\uff0c\u5e7f\u53d1\u8bc1\u5238\u53d1\u5c55\u7814\u7a76\u4e2d\u5fc3<\/p>\n

\n

\u5148\u6765\u770b\u5eb7\u65b9\u751f\u7269\u5bf9HARMONi-2\u4e34\u5e8a\u8bbe\u8ba1\u7684\u5fc3\u601d\u3002\u636eWCLC\u5b98\u7f51\uff0cAK112\u2013303 \/ HARMONi-2\u7814\u7a76\u4f5c\u4e3aLBA\u5165\u90092024WCLC\u5927\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u8be5III\u671f\u7814\u7a76\u65e8\u5728\u6bd4\u8f83\u4f9d\u6c83\u897f\u5355\u6297\uff08AK112\uff09\u5355\u836f\u5bf9\u6bd4\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08K\u836f\uff09\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-L1\u8868\u8fbe\u9633\u6027\u7684\u665a\u671fNSCLC\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5171\u5165\u7ec4398\u4f8b\u60a3\u8005\uff0c\u8bd5\u9a8c\u7ec4\uff08AK112\uff09\u60a3\u8005PD-L1 TPS \u226550%\u30011-49%\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a41.9%\u300158.1%\uff0c\u5bf9\u7167\u7ec4\uff08K\u836f\uff09\u60a3\u8005PD-L1 TPS \u226550%\u30011-49%\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a42.5%\u300157.5%\u3002<\/p>\n

\u636e\u300a\u67f3\u53f6\u5200\u300b\uff0cK\u836fIII\u671f\u4e34\u5e8a\u7814\u7a76KEYNOTE-042\u6570\u636e\u663e\u793a\uff0c\u5728TPS\u226550%\u60a3\u8005\u8eab\u4e0a\uff0cK\u836f\u5355\u836f\u6cbb\u7597\u7684\u6536\u76ca\u5927\u5927\u4f18\u4e8e\u5316\u7597\uff0c\u5728TPS\u4e3a1%~49%\u60a3\u8005\u8eab\u4e0a\uff0cK\u836f\u5355\u836f\u6cbb\u7597\u6536\u76ca\u8f83\u5dee\uff0c\u4e0e\u5316\u7597\u7597\u6548\u57fa\u672c\u4e00\u81f4\u3002<\/p>\n

AK112\u53ef\u8c13\u6253\u4e2dK\u836f\u7684\u8f6f\u808b\uff0c\u73b0\u5728\u6211\u4eec\u56de\u8fc7\u5934\u6765\u770bHARMONi-2\u83b7\u5f97\u7684\u663e\u8457\u9633\u6027\u7ed3\u679c\uff0c\u53c8\u6709\u4e00\u79cd\u4e0d\u540c\u7684\u51b5\u5473\u3002<\/p>\n

\u5728ITT\u4eba\u7fa4\u4e2d\uff0cAK112\u7ec4\u548cK\u836f\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5206\u522b\u4e3a11.14\u4e2a\u6708\u548c5.82\u4e2a\u6708\uff0cPFS HR=0.51\uff08P\uff1c0.0001\uff09\uff0c\u4f9d\u6c83\u897f\u6cbb\u7597\u7ec4\u7684\u75be\u75c5\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e49%\uff1b\u5728ITT\u4eba\u7fa4\u4e2d\uff0c\u572839%\u6210\u719f\u5ea6\u65f6\u8fdb\u884c\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u671f\u4e2d\u5206\u6790\uff08\u672c\u6b21\u5206\u6790\u5206\u914d\u503c\u4ec5\u4e3a0.0001\uff09\u7ed3\u679c\u663e\u793a\uff0cAK112\u5bf9\u6bd4K\u836f\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u751f\u5b58\u83b7\u76ca\uff0cHR=0.777\uff0c\u964d\u4f4e\u6b7b\u4ea1\u98ce\u966922.3%\u3002<\/p>\n

Summit\u4eca\u5e74\u521d\u542f\u52a8HARMONi-7\u7814\u7a76\uff08AK112\u5355\u836f\u5bf9\u6bd4K\u836f\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-\u4e00\u7ebf\u6cbb\u7597\u9ad8\u8868\u8fbe\u665a\u671fNSCLC\u7684\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u7814\u7a76\uff09\uff0c\u4e3b\u8981\u7ec8\u70b9\u8bbe\u4e3aOS\u548cPFS\u3002<\/p>\n

HARMONi-7<\/b>\u5168\u90e8\u5165\u7ec4\u60a3\u8005TPS\u226550%\uff0cK\u836f\u5c06\u4e0eAK112\u786c\u78b0\u786c\u3002 <\/b><\/p>\n

Summit\u4e3b\u5bfc\u5f00\u5c55\u7684HARMONi-3\u7814\u7a76\uff08AK112\u8054\u5408\u5316\u7597\u5bf9\u6bd4K\u836f\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u9cde\u72b6NSCLC\u7684\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u7814\u7a76\uff092023\u5e7410\u6708\u5f00\u59cb\u5165\u7ec4\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3aOS\uff0c\u9884\u8ba14\u5e74\u5de6\u53f3\u5b8c\u6210\u4e34\u5e8a\u30022024\u5e7410\u6708\uff0c\u4e3a\u5b9e\u73b0\u80ba\u764c\u4e00\u7ebf\u5168\u4eba\u7fa4\u8986\u76d6\uff0cSummit\u4fee\u6539HARMONi-3\u4e34\u5e8a\u7814\u7a76\u65b9\u6848\uff0c\u5c06\u5165\u7ec4\u60a3\u8005\u4eba\u7fa4\u4ece\u9cde\u764c\u6269\u5927\u5230\u201c\u9cde\u764c+\u975e\u9cde\u764c\uff08\u817a\u764c\uff09\u201d\uff0c\u8ba1\u5212\u5165\u7ec4\u60a3\u8005\u4ece400\u4eba\u589e\u52a0\u52301080\u4eba\uff0c\u4e3b\u8981\u7ec8\u70b9\u8bbe\u4e3aOS\u548cPFS\u3002<\/p>\n

\u76f8\u6bd4K\u836f\u5355\u836f\uff0cK\u836f\u8054\u5408\u5316\u7597\u66f4\u96be\u4ee5\u88ab\u6311\u6218\u3002<\/b><\/p>\n

K\u836f\u8054\u5408\u5316\u7597\u5728\u4e00\u7ebf\u6cbb\u7597NSCLC\u4e2d\uff0c\u901a\u5e38\u80fd\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e30%\u4ee5\u4e0a\uff0cAK112\u8054\u5408\u5316\u7597\u5728\u4e0eK\u836f\u8054\u5408\u5316\u7597\u7684\u5934\u5bf9\u5934\u8bd5\u9a8c\u4e2d\uff0c\u9700\u8981\u518d\u6b21\u964d\u4f4e20%\u4ee5\u4e0a\u6b7b\u4ea1\u98ce\u9669\uff08OS HR<0.8\uff09\uff0c\u96be\u5ea6\u53ef\u60f3\u800c\u77e5\u3002KEYNOTE-407\u7814\u7a76\u4e2d\uff0c\u4e0e\u5316\u7597\u76f8\u6bd4\uff0cK\u836f\u8054\u5408\u5316\u7597\u663e\u8457\u5ef6\u957fOS\uff0c\u5c06\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e36%\uff08\u4e2d\u4f4dOS\uff1a15.9\u4e2a\u6708vs 11.3\u4e2a\u6708\uff0cHR=0.64[95%CI:0.49-0.85]\uff0cp\uff1c0.0017\uff09\u3002<\/p>\n

AK112\u6d77\u5916III\u671f\u6570\u636e\u5373\u5c06\u8fce\u6765\u7b2c\u4e00\u6b21\u8bfb\u51fa\u3002<\/p>\n

2024\u5e7410\u6708\uff0cSummit\u4e3b\u5bfc\u5f00\u5c55\u7684AK112\u8054\u5408\u5316\u7597\u5bf9\u6bd4\u5316\u75972L\u6cbb\u7597\u63a5\u53d7\u8fc7\u7b2c\u4e09\u4ee3EGFR-TKI\u6cbb\u7597\u540e\u8fdb\u5c55\u7684EGFR\u7a81\u53d8\u7684\u5c40\u90e8\u665a\u671f\u83b7\u8f6c\u79fb\u6027\u975e\u9cde\u72b6NSCLC\u7684\u5168\u7403\u591a\u4e2d\u5fc3III\u671f\u4e34\u5e8a\u8bd5\u9a8cHARMONi\u5b8c\u6210\u60a3\u8005\u5165\u7ec4\uff0c\u9884\u8ba1\u5c06\u57282025\u5e74\u4e2d\u83b7\u5f97HARMONi\u7814\u7a76\u7684\u9876\u7ebf\u6570\u636e\u3002<\/p>\n

02\u00a0<\/strong><\/p>\n

\u5076\u50cf\u5305\u88b1<\/p>\n

AK112\u5934\u5bf9\u5934\u6218\u80dcK\u836f\uff0c\u51c6\u786e\u7684\u8bf4\u6cd5\u662fAK112\u4e2d\u56fd\u4e34\u5e8a\u8bd5\u9a8c\u5934\u5bf9\u5934\u6218\u80dcK\u836f\uff0c\u6216\u8005AK112\u6210\u4e3a\u5168\u7403\u8fc4\u4eca\u552f\u4e00\u5728\u5934\u5bf9\u5934III\u671f\u4e34\u5e8a\u7814\u7a76\u4e2d\u8bc1\u660ePFS\u663e\u8457\u4f18\u4e8e\u836f\u738bK\u836f\u7684\u836f\u7269\u3002<\/p>\n

\u7136\u800c\u4e0d\u5f97\u4e0d\u627f\u8ba4\uff0c\u6218\u80dc\u5168\u7403\u836f\u738b\uff0c\u662f\u4e00\u79cd\u6700\u4f73\u7684\u56fd\u9645\u5316\u53d9\u4e8b\u3002<\/p>\n

\u5eb7\u65b9\u751f\u72692024H2\u4ea7\u54c1\u6536\u516510.6\u4ebf\u5143\uff0c\u73af\u6bd4\u589e\u957f13%\uff0c\u8003\u8651\u5230AK112\u4ece2024\u5e745\u670831\u65e5\u5f00\u59cb\u53d1\u8d27\uff0c\u8fd9\u4e00\u722c\u5761\u901f\u5ea6\u662f\u4e0d\u53ca\u9884\u671f\u7684\uff0c\u4e00\u662fAK112\u4e0a\u5e02\u672a\u5e26\u6765\u660e\u663e\u589e\u91cf\uff0c\u4e8c\u662f\u5728AK112\u7684\u63a9\u62a4\u4e0b\uff0cAK114\u53ef\u80fd\u5df2\u7ecf\u505c\u6b62\u722c\u5761\uff0c\u751a\u81f3\u73af\u6bd4\u4e0b\u964d\u3002<\/p>\n

AK112\u3001AK114\u90fd\u662f\u5e7f\u8c31\u3001\u9ad8\u6548\u3001\u4f4e\u6bd2\u3001\u5dee\u5f02\u5316\u7684\u65b0\u4e00\u4ee3IO\u57fa\u77f3\u836f\u7269\uff0c\u4f5c\u4e3a\u4e2d\u56fd\u6700\u9876\u7ea7\u7684\u521b\u65b0\u836f\uff0c\u56fd\u5185\u5546\u4e1a\u5316\u4e5f\u4e0d\u8fc7\u8fd9\u70b9\u51fa\u606f\uff0c\u5373\u4f7f\u6309\u6700\u75af\u72c2\u7684\u5e02\u9500\u7387\u8ba1\u7b97\uff0c\u4e5f\u8fdc\u8fdc\u4e0d\u80fd\u6491\u8d77\u5343\u4ebf\u5e02\u503c\u3002<\/p>\n

\u6240\u4ee5\uff0c\u4ece\u5e02\u503c\u7ba1\u7406\u7684\u9700\u8981\uff0c\u5076\u50cf\u5149\u73af\u662f\u6709\u5fc5\u8981\u7684\uff0c\u53ea\u662f\u5728\u5b8c\u6210\u9ad8\u4f4d\u914d\u80a1\u3001\u9ad8\u4f4d\u51cf\u6301\u7684\u4efb\u52a1\u540e\uff0c\u5e94\u8be5\u5207\u6362\u5230\u65b0\u7684\u53d9\u4e8b\u3002<\/p>\n

\u4e0eAK112\u7ed1\u5b9a\u8fc7\u6df1\uff0c\u6ca1\u82e6\u786c\u5403\u3002\u4ee5\u5eb7\u65b9\u751f\u7269\u7684\u81ea\u7814\u80fd\u529b\u548c\u7ba1\u7ebf\u5e7f\u5ea6\uff0c\u4e0d\u5e94\u8be5\u6709\u5355\u54c1\u72ec\u5927\u7684\u56f0\u6270\uff0c\u5176\u65e9\u7814\u7ba1\u7ebf\u548cBD\u4e8b\u4ef6\uff0c\u5e94\u8be5\u50cf\u4e0b\u997a\u5b50\u4e00\u6837\u6d8c\u73b0\u3002 <\/b><\/p>\n

\u5eb7\u65b9\u53e6\u5916\u4e00\u4e2a\u5076\u50cf\u5305\u88b1\uff0c\u662f\u4e0d\u613f\u670d\u8f93\u3002<\/p>\n

\u767e\u6d4e\u795e\u5dde\u5927\u5927\u65b9\u65b9\u780d\u6389TIGIT\u6297\u4f53BGB-A1217\uff0c\u5e76\u6ca1\u6709\u8d1f\u9762\u5f71\u54cd\u3002\u4eca\u5e741\u6708\uff0c\u7f57\u6c0f\u57282024\u5e74\u62a5\u4e2d\u5ba3\u5e03\u7ec8\u6b62TIGIT\u6297\u4f535\u9879\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u53ea\u4fdd\u7559\u809d\u764c\u9002\u5e94\u75c7\u7684\u4e34\u5e8a\uff0c\u53bb\u5e7412\u6708\uff0c\u9ed8\u6c99\u4e1c\u4e5f\u5ba3\u5e03\u7ec8\u6b62\u5f00\u53d1TIGIT\u6297\u4f53\u3002TIGIT\u5148\u9a71\u51e0\u4e4e\u5168\u90e8\u6298\u621f\u3002<\/p>\n

\u96be\u6210\u836f\u9776\u70b9\uff0c\u5728\u6d77\u5916\u5927\u5382\u5168\u519b\u8986\u6ca1\u540e\uff0c\u56fd\u5185\u836f\u4f01\u6ca1\u5fc5\u8981\u6b7b\u6491\u3002\u5eb7\u65b9\u7ba1\u7ebf\u7b2c\u4e8c\u9635\u8425AK117\uff08CD47\uff09\u3001AK119\uff08CD73\uff09\u3001AK122\uff08TIGIT\uff09\u3001AK129\uff08PD-1\/LAG-3\uff09\u3001AK130\uff08TIGIT\/TGF- \uff09\u3001AK131\uff08PD-1\/CD73\uff09\u3001AK132\uff08CLDN18.2\/CD47\uff09\u3001AK137\uff08CD73\/LAG-3\uff09\uff0c\u76f8\u5bf9\u8001\u5316\uff0c\u5927\u90e8\u5206\u4e3a\u524d\u4e9b\u5e74\u70ed\u95e8\u800c\u73b0\u5728\u9a8c\u8bc1\u96be\u6210\u836f\u7684\u9776\u70b9\uff0c\u5305\u62ecCD47\u3001CD73\u3001TIGIT\u3002AK117\uff08CD47\uff09\u8fd8\u5728\u575a\u6301\u6700\u540e\u7684\u5014\u5f3a\uff0c\u901a\u8fc7\u4e0eAK112\u8054\u7528\u6765\u4fdd\u7559\u83b7\u6279\u7684\u5e0c\u671b\u3002<\/p>\n

\u8fd8\u662f\u6709\u8fb9\u9645\u6539\u53d8\u7684\u82d7\u5934\u3002\u5eb7\u65b9\u751f\u7269\u9996\u4e2aADC AK138D1\uff08HER3\uff09\u3001\u9996\u4e2a\u53cc\u6297ADC AK146D1\uff08Trop2\/Nectin4\uff09\uff0c\u9776\u70b9\u4e0d\u65b0\u9896\uff0c\u4e5f\u53ef\u4ee5\u7406\u89e3\uff0c\u4f5c\u4e3aADC\u540e\u6765\u8005\u4ee5\u6210\u719f\u9776\u70b9\u5207\u5165\u76f8\u5bf9\u7a33\u59a5\u3002AK135\uff08IL-1RAP\uff09\u3001AK115\uff08NGF\uff09\u3001AK139\uff08IL-4Ra\/ST2\uff09\uff0c\u5177\u6709\u663e\u8457\u7684\u9776\u70b9\u521b\u65b0\u6027\u3001\u75c5\u79cd\u5dee\u5f02\u5316\u3002<\/p>\n

\u675c\u6839\u4e5f\u5e94\u8be5\u653e\u4e0b\u5076\u50cf\u5305\u88b1\u3002Summit\u66b4\u8dcc36%\u4e4b\u540e\uff0c\u5e02\u503c\u4ecd\u6709173\u4ebf\u7f8e\u5143\uff0c\u8c01\u613f\u610f\u5e76\u8d2d\u5462\uff1f\u5176\u5b9e\uff0c\u65f6\u4ee3\u7684\u98ce\u5411\u53d8\u4e86\uff0c\u73b0\u5728MNC\u503e\u5411\u4e8e\u8d2d\u4e70\u65e9\u671f\u7ba1\u7ebf\u8d44\u4ea7\uff0c\u7269\u7f8e\u4ef7\u5ec9\uff0c\u800c\u4e14\u4e34\u5e8a\u5168\u8fc7\u7a0b\u53ef\u7531\u81ea\u5df1\u628a\u63a7\u3002<\/p>\n

Summit\u4f5c\u4e3a\u4e8c\u9053\u8d29\u5b50\uff0c\u4eb2\u81ea\u5bf9AK112\u8fdb\u884c\u5546\u4e1a\u5316\u7684\u53ef\u80fd\u6027\u5f88\u5c0f\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u5269\u4e0b\u7684\u5927\u4e70\u5bb6\u8d8a\u6765\u8d8a\u60ac\u4e86\u3002<\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Summit\u8dcc\u5f97\u4e0d\u51a4\u3002 \u5f00\u59cb\u65f6\uff0c\u6211\u4eec\u9700\u8981\u5398\u6e05\u4e24\u4e2a\u57fa\u7840\u6982\u5ff5\u3002\u4e00\u662fAK112\u5934\u5bf9\u5934\u6218\u80dcK\u836f\uff0c\u5e94\u8be5\u4ee5MRCT\uff08\u56fd\u9645\u591a\u4e2d\u5fc3\u4e34\u5e8a\u8bd5\u9a8c\uff09\u6570\u636e\u4e3a\u51c6\uff0c\u4ee5OS\u4e3a\u80bf\u7624\u7597\u6548\u8bc4\u4ef7\u7684\u91d1\u6807\u51c6\uff08\u8be6\u89c12024\u5e7412\u6708\u300a\u5eb7\u65b9\u64e6\u8fb9\u300b\uff09\uff1b\u4e8c\u662fSummit\u7684\u5e02\u503c\u5927\u53a6\uff0c\u4ee5\u53ca\u5eb7\u65b9\u751f\u7269\u7684\u5927\u90e8\u5206\u5e02\u503c\uff0c\u90fd\u662f\u5efa\u7acb\u5728HARMONi-3\u3001HARMONi-7\u4e24\u9879AK112\u5934\u5bf9\u5934K\u836f\u7684MRCT\u4e4b\u4e0a\uff0c\u4e2d\u56fd\u5355\u533a\u57df\u8bd5\u9a8cHARMONi-2\u4e0d\u80fd\u4e00\u9524\u5b9a\u97f3\uff0c\u53ea\u662f\u524d\u77bb\u6027\u6307\u6807\u3002 \u4e8e\u662f\uff0c\u5d29\u584c\u7684\u903b\u8f91\u4f20\u5bfc\u975e\u5e38\u4e1d\u6ed1\u3002HARMONi-2\u83b7\u5f97OS\u548cPFS\u53cc\u7ec8\u70b9\u663e\u8457\uff0c\u65e0\u53ef\u4e89\u8bae\uff0c\u4f46OS\u7684HR\u4e3a0.777\uff0c\u843d\u57280.8\u7684\u9608\u503c\u9644\u8fd1\u3002\u7f8e\u56fd\u4e34\u5e8a\u80bf\u7624\u5b66\u4f1a(ASCO)\u5728NSCLC\u8bd5\u9a8c\u4e2d\u5b9a\u4e49HR\u4f4e\u4e8e0.8\u7684\u8bd5\u9a8c\u624d\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u3002 \u5728\u6709\u5229\u6761\u4ef6\u4e0b\uff0cHR\u4ecd\u7136\u903c\u8fd1\u9608\u503c\u3002\u8003\u8651\u5230\u6d77\u5916\u4e34\u5e8a\u771f\u6b63\u5177\u6709\u6311\u6218\u6027\uff0cOS HR<0.8\u96be\u5ea6\u9661\u589e\uff0c\u98ce\u9669\u655e\u53e3\u66b4\u9732\u4e86\u3002 HARMONi-3\u9884\u8ba14\u5e74\u5de6\u53f3\u5b8c\u6210\u4e34\u5e8a\uff0c\u5eb7\u65b9\u751f\u7269\u5c06\u5728\u8f83\u957f\u65f6\u95f4\u4e0e\u4e0d\u786e\u5b9a\u6027\u6346\u7ed1\uff0c\u53bb\u5e74\u6709524\u66b4\u8dcc\uff0c\u4eca\u540e\u5462\uff1f\u5176\u5b9e\uff0c\u4f5c\u4e3a\u4e00\u5bb6\u9886\u5148\u7684Biopharma\uff0c\u672c\u6709\u575a\u5982\u78d0\u77f3\u7684\u9884\u671f\uff0c\u4f55\u4ee5\u81f3\u6b64\uff1f 01\u00a0 \u98ce\u9669\u655e\u53e3 \u9ad8\u76db\u62a5\u544a\u9884\u6d4b\uff0cAK112\u57282041\u5e74\u5cf0\u503c\u9500\u552e\u7ea6530\u4ebf\u7f8e\u5143\uff0c\u5e76\u7ed9\u4e88Summit\u00a0\u4f30\u503c300\u4ebf\u7f8e\u5143\u3002 \u9ad8\u76db\u4e0d\u8822\uff0c\u5374\u662f\u771f\u7684\u574f\uff0c\u8d44\u672c\u505a\u5c40\u7684\u9ad8\u624b\u3002 HARMONI-2\u7814\u7a76\u60a3\u8005\u57fa\u7ebf\u72b6\u51b5 \u00a0 \u6570\u636e\u6765\u6e90\uff1aWCLC\uff0c\u5e7f\u53d1\u8bc1\u5238\u53d1\u5c55\u7814\u7a76\u4e2d\u5fc3 \u5148\u6765\u770b\u5eb7\u65b9\u751f\u7269\u5bf9HARMONi-2\u4e34\u5e8a\u8bbe\u8ba1\u7684\u5fc3\u601d\u3002\u636eWCLC\u5b98\u7f51\uff0cAK112\u2013303 \/ HARMONi-2\u7814\u7a76\u4f5c\u4e3aLBA\u5165\u90092024WCLC\u5927\u4f1a\u53e3\u5934\u62a5\u544a\uff0c\u8be5III\u671f\u7814\u7a76\u65e8\u5728\u6bd4\u8f83\u4f9d\u6c83\u897f\u5355\u6297\uff08AK112\uff09\u5355\u836f\u5bf9\u6bd4\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08K\u836f\uff09\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-L1\u8868\u8fbe\u9633\u6027\u7684\u665a\u671fNSCLC\u7684\u6cbb\u7597\u6548\u679c\uff0c\u5171\u5165\u7ec4398\u4f8b\u60a3\u8005\uff0c\u8bd5\u9a8c\u7ec4\uff08AK112\uff09\u60a3\u8005PD-L1 TPS \u226550%\u30011-49%\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a41.9%\u300158.1%\uff0c\u5bf9\u7167\u7ec4\uff08K\u836f\uff09\u60a3\u8005PD-L1 TPS \u226550%\u30011-49%\u7684\u6bd4\u4f8b\u5206\u522b\u4e3a42.5%\u300157.5%\u3002 \u636e\u300a\u67f3\u53f6\u5200\u300b\uff0cK\u836fIII\u671f\u4e34\u5e8a\u7814\u7a76KEYNOTE-042\u6570\u636e\u663e\u793a\uff0c\u5728TPS\u226550%\u60a3\u8005\u8eab\u4e0a\uff0cK\u836f\u5355\u836f\u6cbb\u7597\u7684\u6536\u76ca\u5927\u5927\u4f18\u4e8e\u5316\u7597\uff0c\u5728TPS\u4e3a1%~49%\u60a3\u8005\u8eab\u4e0a\uff0cK\u836f\u5355\u836f\u6cbb\u7597\u6536\u76ca\u8f83\u5dee\uff0c\u4e0e\u5316\u7597\u7597\u6548\u57fa\u672c\u4e00\u81f4\u3002 AK112\u53ef\u8c13\u6253\u4e2dK\u836f\u7684\u8f6f\u808b\uff0c\u73b0\u5728\u6211\u4eec\u56de\u8fc7\u5934\u6765\u770bHARMONi-2\u83b7\u5f97\u7684\u663e\u8457\u9633\u6027\u7ed3\u679c\uff0c\u53c8\u6709\u4e00\u79cd\u4e0d\u540c\u7684\u51b5\u5473\u3002 \u5728ITT\u4eba\u7fa4\u4e2d\uff0cAK112\u7ec4\u548cK\u836f\u7ec4\u7684\u4e2d\u4f4d\u65e0\u8fdb\u5c55\u751f\u5b58\u671f\uff08PFS\uff09\u5206\u522b\u4e3a11.14\u4e2a\u6708\u548c5.82\u4e2a\u6708\uff0cPFS HR=0.51\uff08P\uff1c0.0001\uff09\uff0c\u4f9d\u6c83\u897f\u6cbb\u7597\u7ec4\u7684\u75be\u75c5\u8fdb\u5c55\/\u6b7b\u4ea1\u98ce\u9669\u964d\u4f4e49%\uff1b\u5728ITT\u4eba\u7fa4\u4e2d\uff0c\u572839%\u6210\u719f\u5ea6\u65f6\u8fdb\u884c\u7684\u603b\u751f\u5b58\u671f\uff08OS\uff09\u7684\u671f\u4e2d\u5206\u6790\uff08\u672c\u6b21\u5206\u6790\u5206\u914d\u503c\u4ec5\u4e3a0.0001\uff09\u7ed3\u679c\u663e\u793a\uff0cAK112\u5bf9\u6bd4K\u836f\u5177\u6709\u663e\u8457\u7684\u4e34\u5e8a\u751f\u5b58\u83b7\u76ca\uff0cHR=0.777\uff0c\u964d\u4f4e\u6b7b\u4ea1\u98ce\u966922.3%\u3002 Summit\u4eca\u5e74\u521d\u542f\u52a8HARMONi-7\u7814\u7a76\uff08AK112\u5355\u836f\u5bf9\u6bd4K\u836f\u5355\u836f\u4e00\u7ebf\u6cbb\u7597PD-\u4e00\u7ebf\u6cbb\u7597\u9ad8\u8868\u8fbe\u665a\u671fNSCLC\u7684\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u7814\u7a76\uff09\uff0c\u4e3b\u8981\u7ec8\u70b9\u8bbe\u4e3aOS\u548cPFS\u3002 HARMONi-7\u5168\u90e8\u5165\u7ec4\u60a3\u8005TPS\u226550%\uff0cK\u836f\u5c06\u4e0eAK112\u786c\u78b0\u786c\u3002 Summit\u4e3b\u5bfc\u5f00\u5c55\u7684HARMONi-3\u7814\u7a76\uff08AK112\u8054\u5408\u5316\u7597\u5bf9\u6bd4K\u836f\u8054\u5408\u5316\u7597\u4e00\u7ebf\u6cbb\u7597\u9cde\u72b6NSCLC\u7684\u56fd\u9645\u591a\u4e2d\u5fc3III\u671f\u7814\u7a76\uff092023\u5e7410\u6708\u5f00\u59cb\u5165\u7ec4\uff0c\u4e3b\u8981\u7ec8\u70b9\u4e3aOS\uff0c\u9884\u8ba14\u5e74\u5de6\u53f3\u5b8c\u6210\u4e34\u5e8a\u30022024\u5e7410\u6708\uff0c\u4e3a\u5b9e\u73b0\u80ba\u764c\u4e00\u7ebf\u5168\u4eba\u7fa4\u8986\u76d6\uff0cSummit\u4fee\u6539HARMONi-3\u4e34\u5e8a\u7814\u7a76\u65b9\u6848\uff0c\u5c06\u5165\u7ec4\u60a3\u8005\u4eba\u7fa4\u4ece\u9cde\u764c\u6269\u5927\u5230\u201c\u9cde\u764c+\u975e\u9cde\u764c\uff08\u817a\u764c\uff09\u201d\uff0c\u8ba1\u5212\u5165\u7ec4\u60a3\u8005\u4ece400\u4eba\u589e\u52a0\u52301080\u4eba\uff0c\u4e3b\u8981\u7ec8\u70b9\u8bbe\u4e3aOS\u548cPFS\u3002 \u76f8\u6bd4K\u836f\u5355\u836f\uff0cK\u836f\u8054\u5408\u5316\u7597\u66f4\u96be\u4ee5\u88ab\u6311\u6218\u3002 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